Escherichia coli is a common causative agent of urinary tract infections, which can manifest as frequent urination, urgency, painful urination, fever and chills. For urinary tract infections caused by Escherichia coli infection, treatment is based on medication, while attention needs to be paid to improving lifestyle, as prescribed by the doctor, there is a possibility of complete eradication. 1, drug treatment 1, upper urinary tract infection: common in acute pyelonephritis, can be accompanied by fever, lumbago, preferred intravenous infusion of antibiotics for treatment, commonly used in the application of quinolones, such as ciprofloxacin, ofloxacin, norfloxacin, and cephalosporins, such as cefotaxime, ceftizoxime, ceftriaxone and ceftazidime, etc., can also be applied to aminopenicillin, combined with sulbactam, tazobactam, etc. to improve the symptoms 2, lower urinary tract infection: common in cystitis, urethritis, urine more turbid, can appear burning sensation in the urethra, often oral drug treatment, can be preferred to cotrimoxazole or methotrexate, can also be given cephalosporin, amoxicillin, levofloxacin, furantoin or fosfomycin for treatment. Second, improve lifestyle symptoms gradually disappeared, patients also need to strengthen their own hygiene, diligent change of underwear, try not to stay up late, to ensure adequate sleep, appropriate physical exercise to enhance physical fitness. Ensure adequate water intake daily to facilitate the discharge of inflammatory products, avoid smoking, alcohol, spicy and stimulating food, eat a light diet that is easy to digest, such as rice porridge, egg soup, lotus root powder, noodles, etc. Pay attention to regular review. Third, for female patients, the lack of estrogen after menopause will cause a decrease in lactobacilli in the vagina and an increase in the reproduction of pathogenic bacteria, making it easy to have repeated infections. In addition, if the infection is followed by urinary tract obstruction, recurrence is also likely to occur. The cause should be eliminated promptly, such as surgical drainage or removal of the obstruction. Patients with diabetes mellitus need to be treated aggressively to control blood sugar to reduce the occurrence of infection.