Gray nail, i.e. onychomycosis, is a nail disease caused by the infection of dermatophytes. Early stage of grey nail, i.e., early clinical symptoms of onychomycosis, mainly manifested as limited changes in nail color, nails can become white, yellow, dirty color, etc., and nails will become brittle or easy to separate. The initial treatment method is based on external drugs and oral drugs. 1. Topical medication: antifungal preparations such as 8% cyclopyrrolidone and 5% amorolfine nail coating can be used externally. When localized treatment is used alone, the therapeutic effect is limited because the medication can not penetrate well into the whole nail plate. Therefore, you can choose to use local treatment and systemic treatment jointly, so as to play a certain therapeutic synergistic effect. 2. Oral medication: Oral medication is mainly antifungal drugs such as terbinafine and itraconazole, etc. Combined treatment with topical medication can improve the therapeutic effect. Patients with onychomycosis need to consult a doctor in time, and strictly follow the doctor’s instructions to use the appropriate medication, so as not to cause adverse effects on the body.