Blisters on the feet may be related to a variety of factors, the most common of which are eczema and fungal infections caused by foot odor. In addition, too much friction, burns, mosquito bites, etc. can also lead to blisters on the feet, different causes of specific treatment methods also vary. 1, eczema: is caused by a variety of factors inflammatory skin disease, including food such as fish and shrimp, beef and mutton, etc., inhalants such as pollen, dust mites lead to skin allergies. It often appears as papules and herpes on the basis of erythema, and in severe cases, small blisters, often fused into patches, the boundaries are not clear, often due to scratching to form a point-like vesicular surface. In principle, symptoms should be controlled, recurrence should be reduced, and the patient’s quality of life should be improved by using medications for treatment, such as local application of glucocorticoid cream for anti-inflammation and anti-itching to promote lesion remission, and the antihistamine cetirizine for anti-itching. In daily life, attention should be paid to moisturizing the affected area and avoiding scratching, rubbing, and scraping. 2. Infection: Blisters accompanied by itching can also occur when the feet are infected with bacteria. The common disease is tinea pedis, or foot fungus, and the common symptoms are peeling, maceration, and erosion between the toes, or many blisters on the side of the foot, and those who like to wear impermeable shoes are more likely to develop this disease. Tinea pedis treatment is mainly topical and needs to be adhered to for 1-2 months to completely kill the infected flora. Topical medications such as clotrimazole, econazole, miconazole, terbinafine, and other medications such as compound benzoate ointment, which softens the skin play an auxiliary role; 3. Friction: If there is a sudden increase in exercise or when shoes are not suitable for the feet, blisters can appear due to too much friction. Comfortable and breathable shoes and socks and diligent change of shoes and socks, keep the feet clean and dry, avoid prolonged exercise, blisters do not directly pierce, easy to cause infection, remove the trigger, can be self-absorption, disappear.