Patients presenting with blisters on their feet with itching are usually suffering from tinea pedis or eczema. It is recommended to visit a hospital to clarify the cause and select the appropriate drug dosage according to the type and stage of their lesions. In addition to topical medications, you can also combine oral medications to relieve symptoms: 1. Tinea pedis: Tinea pedis is the most common infectious disease in dermatology, with the main causative agents being Trichophyton rubrum and Trichophyton spp. It has a high incidence and is prone to recurrence or reinfection. It can be treated with azoles such as clotrimazole and bifenazole, or with some preparations with keratin-exfoliating effects such as salicylic acid and tretinoin. In addition, some foreign scholars have used urea ointment in combination with cypionamide cream to treat keratosis pilaris with some efficacy. 2. Eczema: Eczema is a common disease in dermatology, and the pathogenesis is mostly thought to be the result of internal factors of the body, such as abnormal immune function and skin barrier dysfunction, as well as a combination of many external factors. The treatment of eczema is mainly based on local medication. Suitable glucocorticoids can be selected according to the nature of the lesions, such as hydrocortisone, dexamethasone, etc., but it should be noted that the use of glucocorticoids should be carried out under the guidance of a doctor in order to reduce adverse reactions. Non-glucocorticoid drugs, such as tacrolimus ointment and pimecrolimus cream, can also be used without the adverse effects of glucocorticoids and have a high safety profile, helping to stop itching and relieve symptoms. In addition, if the eczema is more serious, please seek immediate medical attention and follow medical advice for systemic medication, such as antihistamines, immunosuppressants, etc.