The causes of itchy, peeling, blistered, rotten feet (clinically known as erosion) in patients are diverse and commonly found in tinea pedis, contact dermatitis, and chronic eczema, and there are differences in medication among the three, which cannot be generalized and thus no best one can say. It is recommended that patients go to a hospital in a timely manner to improve fungal smear testing, patch testing, and other related tests to clarify the cause before proceeding with medication: 1. Tinea pedis: It is transmitted directly or indirectly between people mainly due to moist and sweaty skin on the soles of the feet and between the toes, which provides a good environment for pathogenic bacteria to live and reproduce and the lack of sebaceous glands on the soles of the feet without sufficient unsaturated fatty acids to inhibit ringworm. The occurrence of tinea pedis is related to the degree of sweating and the strength of the immune system of the individual. It occurs on the soles of the feet and between the toes, and is often characterized by blisters, interdigital erosions, itching, thickening of the stratum corneum, and flaking. Patients should first visit a hospital and follow medical advice for topical and systemic medication. Topical medications include wet compresses of boric acid solution, and medications such as tincture of salicylic acid and compound benzoic acid application to promote exfoliation and accelerate the drying of blisters, as well as antibacterial medications such as miconazole, econazole, clotrimazole, and ciclopirox. In addition, if the patient’s tinea pedis is more stubborn, itraconazole, terbinafine, fluconazole, etc. are considered for systemic treatment. 2. Contact dermatitis: It is an acute or chronic inflammatory reaction caused mainly by exposure to animal, plant and chemical substances. The patient’s feet have blisters and rashes at the injury site, and the blisters rupture with vesicles and peeling skin. Medication is mainly directed at systemic and local unfolding, including antihistamines such as cetirizine and loratadine, and in severe cases, methylprednisolone and dexamethasone. If the patient’s symptoms are mainly erythema and papules, boric acid solution can be used as a wet compress, and if there is an infection, topical antibiotics such as mupirocin and neomycin can be used; 3. Chronic eczema: If the affected area of the wounded skin has infiltration, thickening, pigmentation, surface roughness, etc., and accompanied by itching, blisters, erosion, it is considered that it may be chronic eczema. If the symptoms are mild, drugs such as dexamethasone cream and dextran cream can be used to relieve the lesions, while antihistamines such as benadryl and chlorpheniramine can also be used as prescribed to stop the itching and anti-inflammation.