Creatinine and uric acid are two different indicators, high blood creatinine often indicates impaired kidney function, that is, kidney function begins to fail. According to blood creatinine is divided into stages 1-5, stages 1-2 tend to have normal kidney function and creatinine will not exceed the standard, stage 3 starts to have mild creatinine excess, stage 4 significantly exceeds the standard, and stage 5 is the stage of uremia. So creatinine represents the filtration function of the kidney, i.e. the function of the glomerulus is impaired. Blood uric acid can represent whether there is something wrong with metabolism, especially purine metabolism, such as gout. A large percentage of patients with hyperuricemia and gout have good kidney function, but have excessive blood uric acid and normal blood creatinine. These patients often have abnormalities caused by purine metabolism. If there is no joint pain, the doctor may diagnose hyperuricemia; if there is joint pain, it may be gout. Blood uric acid is often an indicator of gout, which is an abnormality of purine metabolism. Some patients have high both indicators because uric acid is excreted from urine through the kidneys, and poor kidney function leads to reduced excretion and elevated uric acid in the blood, so most patients with poor kidney function will have high uric acid. Some patients have high uric acid but good kidney function, these patients often have metabolic problems, probably gout. Some patients have high creatinine but not high uric acid, but these patients also have kidney problems, the renal tubular reabsorption function is affected, that is, the kidney function is impaired. Therefore, high creatinine and high uric acid have crossover conditions, but they are different, depending on the patient’s specific situation.