Low creatinine and uric acid suggest that the patient is likely to have too strict control over diet or has chronic wasting disease. Creatinine and uric acid are both indicators of kidney function, if both are elevated, it indicates kidney failure, which is of great clinical significance. If it is mildly reduced, the clinical significance is not great and generally does not require special treatment. If the decrease is particularly pronounced, then this condition should be taken seriously. Creatinine is the product of muscle metabolism, while uric acid is the product of purine metabolism. If the patient deliberately loses weight, usually is mainly vegetarian, eat lean meat and other food or animal offal, seafood is relatively small, then will cause creatinine and uric acid significantly lower. In addition, some patients have chronic wasting disease, such as tumor, although the diet is still okay, but due to the consumption of the tumor, it will also cause the creatinine and uric acid to decrease significantly. In this case, it is necessary to improve the relevant examination to exclude the possibility of tumor.