The effectiveness of hyperoxia in treating varicose veins is not reliable. Hyperoxia is mainly composed of three oxygen atoms, which is often referred to as the main component of ozone. The cause of varicose veins is the incompetence of the venous valves, and the blood from the deep veins enters the superficial veins, which leads to an increase in venous pressure in the superficial veins and stagnation of blood in the veins, which over time leads to the formation of varicose veins. Ozone has no effect on the repair of venous valves, and it is a superoxide ion, which may cause some damage to the vessel wall and lead to thrombosis under the action of varicose veins, and the patient will show symptoms such as local redness, high skin temperature and pain, so superoxide treatment for varicose veins should not be used at present.