In the risk of gender transmission in HBV-infected patients, regular medical checkups, hepatitis B vaccination for healthy people, timely antiviral for HBV-infected patients, blocking or reducing mother-to-child and father-to-child transmission, and immunization of newborns are all important measures to effectively block gender transmission. 1.Hepatitis B vaccine how to correctly vaccinate? Hepatitis B vaccine requires 3 shots, according to the 0, 1, 6 months program, that is, after the 1st vaccination, the 2nd and 3rd vaccination will be given at an interval of 1 month and 6 months. Hepatitis B vaccination for newborns is required to be given within 24 hours after birth, the earlier the better. For those who are immunocompromised or have no response, the vaccine dose and number of injections should be increased; those who have no response to the 3-vaccination immunization program can be vaccinated with another 3 injections, and anti-HBs in serum can be detected 1-2 months after the second 3-vaccination of Hepatitis B vaccine, and if there is still no response, 1-vaccination of recombinant yeast Hepatitis B vaccine can be given. 2.How to prevent and control hepatitis B if one of the husband and wife has hepatitis B and the other is healthy? The healthy partner should be vaccinated with hepatitis B vaccine or use condom, which can effectively prevent the transmission of hepatitis B virus between husband and wife. 3.How to prevent pre-uterine transmission before pregnancy? Regular review should be conducted, attention should be paid to the detection of serum viral load, and appropriate nucleoside (acid) analog antiviral therapy should be selected, which can effectively prevent and control prenatal hepatitis B transmission. For highly infectious and indicated men with hepatitis B, antiviral treatment should be given to reduce its infectiousness; if highly infectious men with hepatitis B have abnormal liver function but do not consider antiviral treatment for the time being for other reasons, they should be treated with strong hepatoprotective therapy so that their liver function will return to normal, and then give birth to children as soon as possible after stopping the medication for one month. 4.How to prevent intrauterine infection in late pregnancy? Intrauterine infection mainly occurs in the late stage of pregnancy, so hepatitis B immunoglobulin (HBIG) should be injected 200u subcutaneously or intramuscularly in the 28th, 32nd and 36th weeks of pregnancy, which can play a certain immune blocking effect. 5.What is the best delivery method for HBV-infected pregnant women? Amniocentesis should be avoided during delivery, and the delivery time should be shortened to ensure the integrity of the placenta and minimize the exposure of the newborn to maternal blood. Cesarean section is preferred, followed by normal labor and forceps delivery. 6, HBV-infected pregnant women can breastfeeding, HBV-infected pregnant women breast milk contains virus, how much virus and how infectious? It is not clear yet. However, for those who have cracked and broken nipples, broken oral mucosa of newborn babies, increased intestinal permeability due to inflammation of digestive mucosa or direct damage to the mucosa, the hepatitis B virus in the blood mixed with breast milk can enter into the bloodstream through the mucous membrane, thus causing hepatitis B virus infection in infants, therefore, breastfeeding should be cautious for HBV-infected patients, especially for mothers with high viral loads (serum HBV-DNA level >106 copies/mL) should avoid breastfeeding as much as possible, and at the same time pay attention to the protection of daily life, avoiding infants and young children to contact with the body fluids and blood of patients with high viral load, in order to reduce the chance of postnatal infection. 7. How to effectively prevent mother-to-child transmission after the birth of a newborn? Mother-to-child transmission mainly occurs in the perinatal period, mostly from the blood and body fluids of HBV-positive mothers who are untouched during delivery. The interruption rate of mother-to-child transmission with hepatitis B vaccine alone is 87.8%. Newborns of HBsAg-positive mothers should be injected with hepatitis B immune globulin (HBIG) as early as possible within 24 hours after birth (preferably 12 hours after birth), and at the same time receive hepatitis B vaccine at different sites, and the second and third doses of hepatitis B vaccine at 1 and 6 months of age, respectively, which can significantly improve the effectiveness of interruption of mother-to-child transmission. It is also possible to administer 1 dose of hepatitis B immune globulin (HBIG) within 12 hours of birth, followed by a second dose of hepatitis B immune globulin (HBIG) 1 month later, and 1 dose of hepatitis B vaccine at a different site at the same time, with second and third doses of hepatitis B vaccine at intervals of 1 and 6 months, respectively. Neonates of HBsAg-negative mothers were immunized with hepatitis B vaccine. Children who were not immunized against hepatitis B during the neonatal period should be given catch-up vaccination.