Hepatopathic appearance is mostly seen in patients with chronic hepatitis and cirrhosis, and is one of the common clinical manifestations in patients with liver disease. Some patients may also have hyperpigmentation of the face and other exposed areas of the skin, especially around the eyes. These characteristic changes in the face of patients with liver disease are called “hepatopathy face”, which is caused by the increased production of melanin due to the decrease in liver function. In people who have been drinking alcohol for a long time, the liver is damaged and the face will naturally have a cyan or obscure cyan color, which is known as the liver disease face and is a clear sign of liver damage. In patients with cirrhosis, the adrenal glands are hypoactive and the function of the adrenal medulla to synthesize adrenaline is reduced, which affects pigment metabolism and pigments enter the skin, making it darker. In addition, the sympathetic nerve inhibition of melanogenesis in patients with cirrhosis is weakened, prompting an increase in melanin production, which enters the skin and gives rise to hepatopathic appearance.