Although amoxicillin itself does not inhibit acetaldehyde dehydrogenase and does not cause disulfiram-like reactions, alcohol can increase the risk of adverse reactions. However, since alcohol inhibits the activity of hepatic enzymes, drinking alcohol after drug administration will lead to an increase in blood concentration, which in turn will increase the risk of adverse reactions to amoxicillin. For penicillin derivatives, including cephalosporins, it is not recommended that patients consume alcohol, including beer and liquor, within one week after or one week before the application of the drug, at least within three days before and after taking the drug, which may also induce disulfiram-like reactions and cause death or shock. Patients who have a combined cold should drink more water, take more rest, urinate more often, and not stay up late or exert themselves after taking amoxicillin, which can also expand the effect of the drug.