Patients should not smoke when taking amoxicillin because amoxicillin is a common antibiotic that is mainly used to kill the infected bacteria in the body. Usually, due to the decrease of immunity of patients, they are infected by bacteria, which cause inflammation of respiratory system, inflammation of genitourinary system and inflammation of central nervous system, they can take amoxicillin, which can relieve the symptoms and control the inflammation. Patients who smoke can aggravate the condition, especially respiratory inflammation, which can lead to the airway mucosa being stimulated by some harmful chemical components in cigarettes, such as carbon monoxide and tar produced by incomplete combustion, leading to more serious pathological changes in the respiratory mucosa such as congestion, edema, and exudation of inflammatory secretions, which are detrimental to the condition.