The dosage of mannitol for the treatment of lumbar disc herniation is basically under 2g/kg. For most adults, the daily dosage should be under 60g, for example, a 60kg adult, you can start with a small dosage of mannitol, at this time, you can use 20% mannitol injection 125ml, applied twice a day. For such patients must pay attention to the use of mannitol when the adverse effects, because mannitol into the body’s blood after the internal basically do not metabolize, by its original form of the drug gradually excreted through the kidneys, so it may cause a relatively large burden on the kidneys. For patients with renal insufficiency, it is important to reduce the dosage or even not use it as appropriate, and change to other drugs for treatment.