Red blood around the pupil is the presence of neovascularization in the iris. Iris neovascularization is the release of neovascular factors caused by ischemic fundus diseases, such as diabetic retinopathy, ischemic central retinal vein occlusion, central retinal artery occlusion, and ocular ischemia syndromes, leading to neovascularization. Neovascularization is commonly found in the retina, iris, that is, around the pupil and also in the anterior chamber angle, which can cause a series of complications such as increased intraocular pressure, vitreous hemorrhage, anterior chamber hemorrhage, and a drastic decrease in the patient’s vision. If neovascularization is found in the iris, and if it is combined with increased intraocular pressure, it is necessary to first lower the intraocular pressure treatment, and then the vitreous cavity is injected with anti-VEGF drugs, such as razumab. After the intraocular pressure is lowered and the iris neovascularization fades, a dilated fundus examination is needed, and retinal photocoagulation is performed if necessary.