High anti-thyroid peroxidase antibody suggests that autoimmune diseases such as Hashimoto’s thyroiditis and diffuse toxic goiter may have occurred in the thyroid tissue. Patients may have palpitations, fatigue, fear of heat, excessive sweating, or fear of cold, feeling of swelling in hands and feet, drowsiness, memory loss and other symptoms. 1. Hashimoto’s thyroiditis: Most patients with Hashimoto’s thyroiditis have an enlarged thyroid gland. Most patients with Hashimoto’s thyroiditis have changes in thyroid function. In the early stage of the disease, there may be mild hyperthyroidism, such as fear of heat and excessive sweating; while in the later stage of the disease, there are signs of hypothyroidism, such as chills and drowsiness. 2. Diffuse toxic goiter: the disease is a thyrotoxicosis caused by excessive production of thyroid hormone by the thyroid gland itself, leading to a series of hypermetabolic symptoms, such as agitation, restlessness and insomnia, palpitation, fatigue, fear of heat, excessive sweating, lethargy, hyperphagia, increased stools or diarrhea, and scanty menstruation in women. If you find high anti-thyroid peroxidase antibodies, you need to have a detailed examination under the guidance of a doctor to assess the disease and follow the doctor’s instructions for treatment.