Cirrhosis with peritonitis is generally a more serious condition. When liver cirrhosis, liver cells rupture and die, liver function is seriously damaged, resulting in a large amount of ascites accumulation, severe hypoproteinemia in the blood, when cirrhosis is more serious, spontaneous peritonitis can occur, resulting in peritoneal irritation sign, at this time belongs to the stage of progression of cirrhosis, need to be carried out as soon as possible for abdominal drainage and antibiotic treatment to slow down the progress of peritonitis. Cirrhosis is an irreversible liver lesion, and when patients develop cirrhosis, they must be treated in a timely manner, such as regular administration of antiviral drugs such as entecavir, to slow down the progression of cirrhosis and avoid peritonitis. The medication should be administered under the guidance of a physician and should not be self-selected.