For rheumatism combined with high anti-O, one needs to be alert for reactive arthritis. On top of treatment, if there is obvious joint swelling and pain, you need to use non-steroidal pain medication, such as Fotarine extended-release tablets. If the anti-O is much higher, anti-infection treatment is needed. Anti-infection drugs can be chosen from cefoxitin and ceftazidime. After a full course of anti-infection for 10-14 days, sequential benzathine penicillin intramuscular injection is also required at a later stage, initially once a week and later once every three weeks, to monitor the change of anti-O. If the patient has persistent joint pain, immunosuppressive therapy, such as salazosulfapyridine, can be chosen.