There was a typical case consultation about a patient who had inexplicable blisters on his legs, which disappeared for a day or two and kept appearing without interruption. Since it was on the lower extremity, they were worried that this condition of the patient was diabetic foot and called me for consultation in a hurry. According to the pictures, the patient’s condition should be diabetic maculopathy, which is a complication of diabetes mellitus. The characteristics of diabetic maculopathy often appear in the distal extremities, such as the foot, calf, hand, forearm, etc. The blisters are usually small, about 0.5 cm, and the fluid is roughly plagioid and viscous, or they can be hemorrhagic, with a rapid onset and acute onset. If the blisters break down and form an infection, they will remain untreated for a long time to form a chronic wound, which has a particularly great impact on the physical and mental health of the patient. It is usually found in patients with a long course of disease, especially in those with neuropathy, nephropathy, retinopathy, and, in a few cases, as a precursor to the development of diabetes. At present, the mechanism of its pathogenesis is not too clear, some experts speculate that it may be related to the following factors: 1, diabetic microangiopathy is the basis, hyperglycemia cell inositol metabolism is abnormal, sorbitol metabolism is active, resulting in increased vascular permeability; in this way, the fluid is easy to penetrate out to form blisters or blood blisters. 2, peripheral nerve dystrophy, malnutrition leads to abnormal skin metabolism, degeneration of basal cells and epidermal cell lysis necrosis, skin structure changes and blisters appear, cellular tissue fluid exudation. 3, renal lesions, calcium and magnesium ion balance imbalance, mostly seen in diabetic uremia, resulting in fragile skin structure, the formation of blisters after heat, friction and other damage. From the above, the appearance of blisters is still related to a variety of complications, so we should pay attention to the control of blood sugar to avoid complications. However, what should be done if diabetic blisters have already appeared? This is definitely a situation that needs to be taken to the hospital and left to the doctor. Generally, such blisters will mostly absorb on their own, and they will not leave significant scars after absorption. But if it accidentally breaks or is not absorbed, such a blister will easily become infected and in the foot’s it will develop into a diabetic foot. Therefore, I recommend that you should visit a department that specializes in the treatment of diabetic foot and other slow trauma to avoid the risks associated with blister breakage and to be able to prevent the wound from causing infection in the first place. If the infection is unfortunately already present, it is recommended to treat it promptly with a combination of Chinese and Western medicine to avoid erosion of more healthy tissues.