This is a common situation, many diabetic patients will feel a burning sensation in the lower limbs, as if there is a fire burning fire, what is wrong with this? For your information, this is most likely caused by peripheral neuropathy, a complication of diabetic foot, which is also an early symptom of diabetic foot, and if it continues to develop without treatment it is likely to develop into diabetic foot. Neuropathy is one of the complications of diabetes and is the result of a combination of factors, including metabolic disorders, vascular damage, neurotrophic factor deficiency, cytokine abnormalities, oxidative stress and immune factors all play a role. In addition, glucose auto-oxidation leads to the formation of reactive oxidative products, resulting in cellular oxidative stress and mitochondrial dysfunction, which, in short, has a very complex pathogenesis. Diabetic peripheral neuropathy is characterized by symmetrical pain and sensory abnormalities in the clinical setting, with symptoms more common in the lower extremities than in the upper extremities. Sensory abnormalities include numbness, ankylosis, insect crawling, heat, electric shock-like sensations, or sock- and glove-like sensations. The pain may be stabbing, burning, gouging, or seemingly deep in the bone marrow, sometimes as if it were an amputation-like pain. The pain may be lighter during the day and heavier at night. When the motor nerve is involved, there is often varying degrees of muscle strength loss. The degree of neuropathy can be mild or severe, and some people do not have much impact on their lives, while other patients have significant symptoms. He was a typical peripheral neuropathy patient from Guangdong who had to soak his feet in ice water all the time to get relief from the severe burning. Although he was cured by the combination of Chinese and Western medicine in our hospital, I still want to remind everyone that as soon as neuropathy is diagnosed, you should immediately consult a hospital for a systematic and clear examination, and a specialist will develop a corresponding treatment plan. Because neuropathy can also lead to decreased sensitivity of the lower extremities, it is not uncommon for patients to have their feet stabbed by nails, their legs cut by sharp objects, or their feet burned by washing! And these are not found in time because they are not felt, and when they are found they are often already serious. So, the killing power of neuropathy is still very big and powerful. Of course, the best way or to do a good job of prevention, I give the following suggestions: 1, control blood sugar, blood pressure and lipids. 2, strengthen foot care, every day, dragged socks to check the feet. 3, regular screening and assessment of the disease, and do intervention one day earlier. 4.See a doctor promptly when early symptoms appear. Finally, if people have foot ulcers and infections due to neuropathy, don’t worry and be afraid, they can heal quickly through timely and effective treatment.