Lung adenocarcinoma stage III with lymph node metastasis can be treated with drug therapy, surgery, radiotherapy and immunotherapy. 1. Drug treatment: For patients who have been diagnosed with lung adenocarcinoma with lymph node metastasis, drug treatment is necessary, and it is recommended to choose molecular targeting drugs, such as gefitinib, afatinib, ositinib, etc. 2. Surgery: Lung adenocarcinoma is usually treated by surgery according to the specific stage. Surgery for patients with stage III disease can be performed by removing the infested soft tissues of the lung lobes and performing mediastinal lymph node dissection. 3. Radiotherapy and immunotherapy: For patients with stage III lung adenocarcinoma with lymph node metastasis, radiotherapy as well as immunotherapy can be carried out at the same time of chemotherapy to reduce the local recurrence rate. It is suggested that patients with metastatic lymph nodes of stage III lung adenocarcinoma should choose regular hospitals and under the guidance of doctors for treatment.