When middle-aged and elderly people have pain in the back, back, ribs, limb joints and other parts of the skeleton, they often think they have “osteoporosis”, “osteophyte disease”, “lumbar muscle strain “Therefore, in most cases, they will go to orthopedics, rheumatology, acupuncture and massage departments for consultation and treatment, and some patients do not want to go to the hospital and simply buy some calcium tablets and Some patients do not want to go to the hospital and simply buy some calcium tablets and painkillers to solve their problems. In fact, in addition to the above-mentioned diseases that cause bone pain, there is another kind of blood tumor that is often overlooked and easily misdiagnosed and missed – multiple myeloma! In recent years, the incidence of multiple myeloma has been increasing with the aging of China’s population and environmental pollution. This disease has a slow onset, insidious symptoms and non-characteristic clinical manifestations, so it is very difficult to be discovered and detected in the early stage. When patients develop symptoms, such as bone pain, fracture, hypercalcemia; anemia, bleeding; proteinuria and renal impairment; recurrent infections and fever; hepatosplenomegaly and amyloidosis, most of them reach the middle and late stages of the disease. In clinical practice, we often encounter cases of multiple myeloma developing into spinal cord compression and spinal cord paraplegia, where the patient is unable to move his lower body, incontinent, with a particularly poor quality of life, and needs to be waited on by someone, which is a great pity! In fact, this disease can be prevented from developing into spinal cord paraplegia if it is diagnosed and diagnosed early, and treated early and standardized. Because of the diverse manifestations of the disease, the symptoms are not specific, and the diagnosis of the disease requires bone marrow aspiration, biopsy, serum protein electrophoresis, immunoglobulin quantification and skeletal X-ray, which are more specialized tests, and bone marrow aspiration is feared by most patients, so the misdiagnosis rate of the disease at the first diagnosis is extremely high, with some literature reports reaching more than 70% to 80%. The author also frequently sees patients with multiple myeloma referred from orthopedics, nephrology, rheumatology, etc. This affects the timely treatment, survival and quality of life of patients to a certain extent, so how can this disease be detected in a timely manner? — Middle-aged and elderly people with unexplained bone pain, or pathological fractures; or unexplained anemia; or unexplained proteinuria and renal insufficiency; or recurrent lung infections should see a hematologist promptly to rule out the disease as soon as possible. — Routine examination reveals urine protein, anemia, significantly increased sedimentation, increased globulin, osteolytic changes on skeletal X-ray, or pathological fracture or spinal compression fracture, you should see a hematologist promptly to exclude multiple myeloma. –Bone marrow examination is not damaging to the body! If the doctor recommends sexual bone marrow examination to exclude this disease, the patient should actively cooperate with the doctor for bone marrow aspiration, bone marrow biopsy, blood and urine immunoelectrophoresis, etc., in order to confirm the diagnosis of myeloma in a timely manner. In conclusion, bone pain is an early warning sign of this disease, and unexplained anemia and renal impairment should be noted to rule out multiple myeloma! Middle-aged and elderly people should pay enough attention to the above-mentioned discomfort in order to seek timely medical treatment.