Superficial gastritis can take amoxicillin, clarithromycin, levofloxacin and other drugs for anti-inflammatory. Superficial gastritis indicates that the superficial part of the gastric mucosa is congested and edematous, the condition is relatively mild, and some patients have no symptoms, some superficial gastritis will have recurrent episodes, which is related to the infection of Helicobacter pylori, and it is necessary to use anti-inflammatory drugs in the treatment. Amoxicillin is a relatively common anti-inflammatory drugs, belonging to the penicillin class, the drug has a broad-spectrum antibacterial effect, for a variety of bacteria have a killing effect. Clarithromycin is an anti-inflammatory drug belonging to the class of macrolides, which can not only be applied in the treatment of respiratory system diseases, but also has a therapeutic effect on digestive system infections. Levofloxacin belongs to the quinolone class of anti-inflammatory drugs, the antibacterial property of the drug is relatively broad, and relatively few side effects on the human body. For patients diagnosed with Helicobacter pylori infection, the best choice of anti-inflammatory drugs is a combination of two drugs, which can better play the role of the drug, and should also be combined with an acid-suppressing drug, such as omeprazole, which can destroy the environment of the Helicobacter pylori bacteria and improve the cure rate.