Drinking leg pain may be caused by vasodilatation, production of large amounts of acetic acid, and induced gout, etc. You should consult a doctor in time to find out the cause of the disease. 1. Vasodilatation: after drinking alcohol, the blood vessels of the lower limbs, especially the calves, may dilate, local metabolism is accelerated, and the anaerobic metabolism in the calf muscles increases, thus causing the accumulation of acidic metabolites and leading to the clinical symptoms of calf pain. 2. Produce a large amount of acetic acid: a large amount of ethanol is ingested during the drinking process, and ethanol is metabolized into acetaldehyde and acetic acid in the body. If you drink too much alcohol, acetaldehyde and acetic acid are not fully metabolized in the liver and will accumulate in the blood. As the blood spreads throughout the body, acetic acid can enter the calf through blood circulation, stimulating the calf nerves and causing clinical symptoms of calf pain. 3. Induce gout: If you have a history of gout, drinking alcohol will promote the conversion of adenine nucleotides, which may cause an increase in purine and uric acid in the body, and alcohol is metabolized in the body to produce lactic acid, which can inhibit the excretion of uric acid by the kidneys, and when the excretion of uric acid decreases it will lead to an increase in blood uric acid in the blood, and an increase in uric acid will lead to the patient’s leg pain. There may be other reasons for drinking leg pain, you should consult a doctor to clarify the specific cause and treat accordingly if necessary.