Thyroglobulin antibodies of 4000IU/ml are indicative of autoimmune thyroiditis. If the thyroid function is normal, it is not serious; if hypothyroidism is present, it is more serious and requires treatment. Elevated thyroglobulin antibody suggests autoimmune thyroiditis, thyroglobulin antibody 4000IU/ml has exceeded the normal value by many times, the higher the value, the more serious the immune destruction. Elevated thyroglobulin antibodies should also be referred to thyroid function. If hypothyroidism is present, thyroid hormone replacement therapy is needed under the guidance of a doctor. If the thyroid function is normal and only the thyroglobulin antibodies are elevated, the condition is not serious and can be reviewed regularly. If the thyroglobulin antibodies are abnormal, the patient should consult a doctor and follow the doctor’s instructions.