Linaclotide is a guanylate cyclase C agonist with visceral analgesic and pro-secretory effects. The drug is indicated for the treatment of constipated irritable bowel syndrome in adults. It increases the secretion of chloride and bicarbonate in the lumen of the small intestine, which ultimately leads to an increase in the secretion of small intestinal fluids and an increase in the rate of colonic transit, improving constipation. The drug can be seen in viral gastroenteritis, metabolic diseases and malnutrition, headache, dizziness, diarrhea, abdominal pain, bloating and other adverse reactions.The drug is contraindicated in children under the age of 6 years, patients suffering from mechanical gastrointestinal obstruction, as well as in those who are allergic to the drug. The use of the drug should be noted that before use need to exclude intestinal organic diseases; diarrhea may occur during the use of the drug, if persistent or severe diarrhea, should immediately stop using the drug and promptly seek medical attention. If you need to use the drug patients, please in the doctor and pharmacist under the guidance of strict compliance with medical advice to take medication, do not self-medication.