Pain in the bladder reflex zone on the bottom of the foot is mostly due to localized long-term chronic strain, causing sterile inflammation. It is important to pay attention to rest, avoid walking long distances, and avoid standing for long periods of time. During the onset of pain, most of the conservative local treatment methods are used. Local hot compress and massage can be given appropriately, and it can also be combined with acupuncture, infrared radiation and other treatments. After local hot compress, local medication can be given, such as local application of diclofenac diethylamine latex, or local application of blood-activating and pain-relieving cream. For particularly severe pain, oral non-steroidal anti-inflammatory and analgesic drugs, such as loxoprofen sodium, can also be administered. If the pain is caused by local bacterial infection, most of them are accompanied by obvious redness, swelling and heat, and require targeted anti-infection treatment, which can be done by applying erythromycin ointment topically. If it is caused by fungal infection, targeted antifungal treatment is needed, such as topical application of ketoconazole cream.