There is no such thing as the best nemesis for severe constipation. Patients with severe constipation can improve their condition by improving their lifestyle, medication and surgery. 1. Improve lifestyle: eat more fruits and vegetables to increase dietary fiber, drink more water, quit smoking and drinking, develop the habit of regular defecation, moderate exercise to promote gastrointestinal peristalsis to promote defecation, abdominal massage, to ensure that the bowel movement. 2. Medication: Under the guidance of a doctor, you can use mosapride and other gastrointestinal power drugs to promote gastrointestinal peristalsis; lubricants such as Keserol to assist in defecation; osmotic laxatives such as lactulose to promote defecation; magnesium sulfate and other salt laxatives. 3. Surgery: For patients with organic lesions of the gastrointestinal tract, such as tumors, intestinal adhesions, intestinal obstruction and so on, surgical treatment is needed. It is recommended that patients with severe constipation that can not be relieved should consult the doctor in time, improve the relevant examination to clarify the cause of the disease, and make reasonable treatment plan according to the condition under the guidance of the doctor.