The weakness caused by low platelets is categorized into mild and severe: 1. Mild weakness requires bed rest. 2. Severe malaise needs to go to hospital for treatment. Platelets in the body are produced by bone marrow megakaryocytes, and their normal value is (100~300)×10⁹/L. Platelets contain 5-hydroxytryptophan, and an important function of 5-hydroxytryptophan is to increase the body’s excitatory neurotransmitters. When platelets decrease in the body, the level of 5-hydroxytryptophan also decreases, so you may feel lack of energy and can’t lift your strength, which leads to a feeling of weakness. Low platelets combined with fatigue need to pay attention to whether the patient is anemic, and further examination is needed to clarify the cause of the disease. Such as aplastic anemia caused by low platelets need to be taken orally cyclosporine and other drugs. Only by accepting the formal treatment of the cause of the disease, platelet index recovery, fatigue symptoms can be fundamentally improved.