Lupus erythematosus headache needs to be treated according to the causes of headache, common causes include lupus encephalopathy, elevated blood pressure, neurogenic headache, infection and so on, which need to be treated according to different causes. 1. Lupus erythematosus causes headache for many reasons, choose the appropriate treatment for different causes. (1) Lupus erythematosus headache is caused by lupus erythematosus encephalopathy, which is a severe form of lupus and needs to be treated with glucocorticoid such as methylprednisolone shock and immunosuppression such as cyclophosphamide. (2) Lupus erythematosus headache, if it is caused by increased blood pressure, need to give nifedipine and other antihypertensive drugs in time to control blood pressure. (3) If the headache of Lupus erythematosus is vasoneurotic headache, which is related to fatigue and tension, anti-inflammatory and analgesic treatments such as non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen may be considered. (4) Lupus erythematosus headache, such as fever, infection and other factors need to be based on drug sensitivity test to choose the appropriate drug treatment, such as cefuroxime anti-infection treatment. 2. Lupus erythematosus can also be combined with cerebrovascular accident, cerebral space occupation, subarachnoid hemorrhage, etc., which can cause headache, and need to be treated by specialists in a timely manner. Patients with lupus erythematosus who have headache are advised to go to the rheumatology and immunology department of the hospital in time to get standardized diagnosis and treatment.