The cure for depression may require a combination of psychotherapy (e.g. cognitive behavioral therapy, etc.), medication (e.g. fluoxetine, sertraline, etc.), and physical therapy (repetitive transcranial magnetic stimulation, convulsion-free electroconvulsive shock, etc.). 1. Psychotherapy: Doctors can adjust the negative cognition of depressed patients through cognitive-behavioral therapy and other methods, and also help patients to improve the interpersonal relationship mode to a certain extent. 2. Medication: It is the most important method to treat depression. Commonly used antidepressants, such as fluoxetine and sertraline, are selective 5-hydroxytryptamine reuptake inhibitors, and their adverse reactions are gastrointestinal reactions (such as nausea, indigestion, etc.), insomnia, and so on. 3. Physical therapy: Repetitive transcranial magnetic stimulation, non-convulsive electroconvulsive therapy, etc. are common, suitable for use in adjunctive medication or to achieve rapid onset of action. The cure of depression needs to be under the guidance of doctors and the cooperation of patients and their families, need to consult the doctor as early as possible, do not blindly take medication or treatment on your own, so as not to delay the condition.