Artificial insemination and in vitro fertilization are two different ways of assisting pregnancy, each with its own indications. Artificial insemination is the process of injecting the optimized sperm of the male partner into the uterine cavity of the female partner after the follicle of the female partner has matured, so as to let the sperm and the egg combine freely and inseminate, which is mainly adapted to the infertility patients whose fallopian tubes are open, and the process is simple, the technology is mature, the cost is low, and the probability of getting pregnant is 10%-15%. In vitro fertilization (IVF) is a process in which the woman retrieves eggs after ovulation stimulation and the follicle matures, and the man retrieves sperm on the same day as the woman retrieves eggs, and the sperm and eggs are fertilized outside the body to form embryos, which is a relatively complicated process, costing an average of 30,000 yuan for one cycle, and the success rate of our center is about 50%-60%. Endometriosis, IUI failure for 2-3 cycles. For men: severe oligozoospermia, obstructive azoospermia, deformed spermatozoa. Due to the simplicity of the technology and narrow indications, the success rate of pregnancy is relatively low. In addition, not all patients can do several cycles of artificial insemination first, and then switch to IVF after unsuccessful, artificial insemination has certain requirements for the female’s fallopian tubes and the male’s sperm count. If the conditions are met, then 2-3 cycles of IUI can be done and IVF can be switched to IVF if there is no pregnancy, if the conditions are not met, IVF can be considered directly. Because the indications for IVF are relatively broad and the success rate is high. Therefore, after the failure of artificial insemination, patients can consider IVF, but the specific conditions need to be evaluated by the doctor according to the specific situation after coming to our fertility center.