The treatment plan for breast nodules should be based on the patient’s condition, and there is no absolute fastest way to disperse the nodules. Benign nodules are treated by drugs and surgery, and malignant nodules are treated by targeting and surgery. 1. Benign nodules are treated with medication and surgery. (1) Drug treatment, commonly used antibiotics such as penicillin, etc., is suitable for patients with breast infection or trauma resulting in breast nodules. (2) Surgical treatment, there are McMurtry surgery and mastectomy. McMurtry surgical therapy is suitable for benign nodules smaller than 3 centimeters. Mastectomy is indicated for patients whose benign tumors are too large for minimally invasive surgery. 2. Treatment of malignant tumors includes endocrine drug therapy, targeted drug therapy, and surgical therapies such as modified radical mastectomy and breast-conserving surgery. (1) Drug therapy, endocrine therapy is used for patients whose pathologic biopsy suggests that sex hormone receptors are positive, and commonly used drugs include tamoxifen and letrozole. Targeted therapy is used for patients with positive pathologic Her-2 receptor, and commonly used drugs include Herceptin. (2) Surgical treatment, modified radical mastectomy requires removal of the entire breast and clearance of axillary lymph nodes. Breast-conserving surgery requires complete lumpectomy and biopsy of the anterior lymph nodes, and the decision of whether to clear the axillary lymph nodes is based on the biopsy results, and patients undergoing breast-conserving surgery need postoperative radiotherapy. If breast nodules are diagnosed, it is recommended to seek timely treatment to avoid delay.