There is no pain relieving drug that is good for every patient with advanced lung cancer, and the drug that is suitable for the patient is the better drug. Ibuprofen, tramadol, morphine and so on are commonly used painkillers in advanced stage of lung cancer, and patients need to follow the doctor’s instruction to use these drugs. 1. Ibuprofen: Ibuprofen belongs to non-steroidal anti-inflammatory drugs, which reduces the synthesis of prostaglandins through the inhibition of cyclooxygenase, so as to alleviate the pain caused by prostaglandins and reduce the sensitivity of peripheral nerves to nociception. 2. Tramadol: a weak opioid central analgesic, belonging to the second-order cancer analgesic, which mainly achieves analgesic effect by acting on the specific receptors related to pain in the central nervous system. 3. Morphine: it is an opioid agonist and belongs to the third-order analgesic drugs for cancer, which can inhibit the release of substance P by binding with opioid receptors in different parts of the brain, thus interfering with the transmission of pain impulses to the central nervous system and exerting analgesic effects. Patients should take the medication as prescribed by the doctor, avoid self-medication, and should consult the doctor in time if any discomfort occurs after taking the medication.