Often midnight upset stomach is considered to be indigestion, peptic ulcer, chronic gastritis and other diseases caused by acid inhibitors, pro-dynamic drugs, gastric mucosa protection drugs, antibiotics and other drugs to treat. 1. Dyspepsia: patients can be due to abnormal digestive function, resulting in the accumulation of food in the gastrointestinal tract, appearing in the midnight stomach discomfort. At this time, patients can take compound digestive enzymes and other digestive enzyme preparations, accompanied by gastric dyskinesia patients can also take domperidone, mosapride and other prokinetic drugs. 2. Peptic ulcer, chronic gastritis, etc.: patients with this kind of disease are usually accompanied by increased secretion of gastric acid, you can take omeprazole, ranitidine and other acid inhibitors to inhibit the secretion of gastric acid, you can also take bismuth potassium citrate, magnesium aluminum carbonate and other gastric mucosal protection drugs to reduce the stimulation of the gastric mucosa of the food, gastric acid, etc., and alleviate the symptoms of gastric discomfort in the middle of the night. 3. Helicobacter pylori infection: If the patient is clearly infected with Helicobacter pylori, eradication treatment should be carried out in time, and often take quadruple therapy, that is, a proton pump inhibitor (such as omeprazole, lansoprazole, etc.) + two antibiotics (amoxicillin, clarithromycin, metronidazole, etc.) + a bismuth agent (such as bismuth potassium citrate, bismuth pectin, etc.). If the patient often appears midnight stomach discomfort, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment. Drugs need to be taken in strict accordance with the doctor’s prescription, not self-medication, so as not to delay or even aggravate the condition.