Michael Daugherty et al. from the Department of Urology, State University of New York Upstate Medical University, published an article in The Journal of Urology in 2015 on the high prevalence of suspicious cell kidney cancer in young women, and while young patients may develop kidney cancer due to genetic factors, there is also a subset of patients who have neither a family history nor a known Therefore, the main purpose of this article was to investigate the differences in the histological distribution of kidney cancer in young patients compared to older patients. The study queried all patients aged >20 years who had undergone surgical treatment for kidney cancer between 2001 and 2008 from the SEER 18 registry. Four cohorts were created based on sex, age ≤40 and >40 years, and differences in histologic distribution between cohorts were compared using chi-square tests. RESULTS: Although clear cell carcinoma remained the most common RCC in all cohorts, smallpigmented cell carcinoma was the predominant type of non-clear cell carcinoma in young women, accounting for 62.3% of all non-clear cell carcinomas (p < 0.0001). In other groups, papillary renal cell carcinoma remained the most common type of non-clear renal cell carcinoma.