Atypical fatty tumor is also known as highly differentiated liposarcoma. Diagnosed with highly differentiated liposarcoma, you need to actively cooperate with the doctor’s treatment, common treatments are surgery, radiation therapy, targeted therapy, etc., which should be carried out in accordance with the doctor’s instructions. Liposarcoma often occurs in the deep soft tissue, retroperitoneum and other parts of the body. It is mostly nodular or lobular in appearance, and may resemble lipoma, or may be mucus-like or fish-like. Among the liposarcomas, the treatment strategy and outcome of liposarcoma differ completely depending on the pathologic type of liposarcoma. For highly differentiated liposarcomas, surgery is the mainstay of treatment. Mucinous liposarcomas are more sensitive to radiotherapy, with a 5-year control rate of 97%. The chemotherapy regimen of doxorubicin combined with isocyclophosphamide is ineffective in the treatment of highly differentiated liposarcoma, so chemotherapy is usually not used. Some multi-targeted targeted drugs are also effective for liposarcoma, such as: sorafenib, sunitinib, and anilotinib. Patients should actively cooperate with the doctor’s treatment, do not self-medication, so as not to delay the condition or adverse reactions.