Whether the swelling of epididymis can be cured by itself depends on the cause of the disease. The swelling of epididymis caused by trauma may be cured by itself, while the swelling of epididymis caused by epididymitis or epididymal tuberculosis usually cannot be cured by itself. 1. Trauma: Epididymal enlargement caused by trauma, if the symptoms are relatively mild, after a period of rest, there is a possibility of self-healing. 2. Epididymitis: the swelling of epididymis caused by epididymitis usually cannot be cured by itself, and it needs to be treated with antibiotics such as erythromycin, ofloxacin, and so on, and can be combined with some non-steroidal anti-inflammatory drugs, such as acetaminophen and ibuprofen when there are painful symptoms. 3. Epididymal tuberculosis: Epididymal enlargement caused by epididymal tuberculosis can not be cured, need to use rifampicin, isoniazid and other anti-tuberculosis drugs for treatment, and serious symptoms need to take surgical treatment. Epididymal enlargement should actively seek medical treatment under doctor’s guidance, so as to avoid aggravation of the condition.