Case sharing: male, 32 years old, because of “arthritis”, listen to folk doctors, the use of Lei Gongteng wine, taking 1 week, weakness, yellow urine symptoms, in the local investigation of liver function is obviously abnormal urgently transferred to our hospital for treatment, our hospital in accordance with the condition of the rapid changes in the laboratory tests show that the liver function indexes are serious deterioration of the diagnosis of severe liver disease, drug liver may be given rescue treatment. The drug liver may be, was given rescue treatment. After two weeks of treatment, the condition gradually stabilized, and common causes such as viral hepatitis and autoimmune liver disease were ruled out, and liver pathology was examined to clarify the cause of the disease. Pathological interpretation: hepatocyte arrangement disorder, cellular edema, hemorrhage around the central vein, fusion necrosis, the formation of bridging necrosis, fusion into a piece, hepatic sinusoidal enlargement, hepatocyte sludge, lymphocyte infiltration is dominated by eosinophils, neutrophils, bile ducts damage is not obvious, there is a bile duct reaction, and confluent area fibrosis is not obvious. Typical drug injury. Leigongteng (TWHF) is a vine plant of the family of Wesleyanaceae, which was firstly included in Shennong’s Classic of the Materia Medica (神农本草经), is highly toxic, and belongs to the liver and kidney meridians, and it has the efficacy of dispelling wind and removing dampness, invigorating blood circulation, subduing swellings and relieving pain. Modern research shows that Lei Gong Teng has a complex chemical composition, from which about 80 kinds of substances have been isolated, mainly diterpenoids, triterpenoids, alkaloids and sugars, etc., of which alkaloids and terpenoids are the main active ingredients, with anti-inflammatory and analgesic, anti-tumor, immunosuppressive and other pharmacological effects, and it has been widely used in the treatment of renal disease, rheumatism, dermatological diseases, hematological diseases, tumors, etc., and the therapeutic efficacy is exact. It is highly favored. However, with the wide application of clinical, Lei Gongteng showed obvious toxic side effects, the National Center for Adverse Drug Monitoring reported that since January 2004-September 2011, Lei Gongteng adverse reactions reported a total of 633 cases, but due to China’s adverse drug reaction reporting system is incomplete, this is only the tip of the iceberg. The main manifestation is drug liver injury, and the hepatotoxicity caused by it ranks first among the liver injuries caused by single-flavored Chinese herbs in the relevant reports.