The four early manifestations of hypothyroidism in children are special appearance, abnormal physical development, abnormal motor development, and neurological abnormalities. 1. Special appearance: children with hypothyroidism will have the symptom of mucous edema, which is mainly manifested as bloating of the whole body, which is obvious on the back of the neck, back of the hands, abdomen, etc., with a large and thick tongue, yellowish and sparse hair, and rough skin. 2. Abnormal physical development: children suffering from hypothyroidism, their growth and development will also be seriously affected, can show disproportionate short stature, large head, short neck, short limbs, trunk is relatively long, fontanel closure is late, delayed teething. 3. Abnormal motor development: the motor development of children with hypothyroidism will also be delayed, such as sitting, crawling, standing, walking are behind their peers, and can not accurately grasp small things. 4. Nervous system abnormality: hypothyroidism children’s intelligence is generally lower than that of their peers, manifested as quiet and less crying, dull expression, slow reaction. Children with hypothyroidism may also have other manifestations, it is recommended to go to the hospital in a timely manner, improve the examination to determine the cause of the disease, and then give targeted treatment or therapy.