If there are blisters on the vulva, there are two common causes: the first is genital herpes caused by herpes simplex virus infection, which is often accompanied by vulvar itching, and once the blisters rupture, there will be severe pain. Clinical antiviral treatment can be applied locally with acyclovir ointment, as well as strengthening nutrition and improving resistance, which will help the disease to heal as soon as possible. In addition, it is also recommended that the diet should not eat acidic and spicy stimulating food. The second one, caused by herpes zoster, is a condition that causes severe pain and makes it difficult for the patient to sleep. In addition to giving symptomatic treatment in the clinic, the main treatment is pain relief and improving the immunity of the body, mainly due to the decline of the body’s resistance to the occurrence of shingles.