A positive Murphy’s sign is most often considered a possibility that the patient is having an acute gallbladder attack or an acute attack of chronic cholecystitis. When acute cholecystitis or an acute attack of chronic cholecystitis occurs in the body, it will show enlargement of the gallbladder and bile stasis, which further causes inflammation of the gallbladder. Ultrasound examination of the upper abdomen will indicate grossness within the gallbladder wall and the possibility that some patients may have a gallbladder stone lodged in the neck of the gallbladder. When the patient is examined by the doctor, the doctor’s left hand is placed at the midpoint of the right side of the patient’s rib cage and the patient is asked to inhale, the patient will stop inhaling and experience severe right upper abdominal distension and colic. The patient needs to have an ultrasound of the upper abdomen, as well as blood tests such as routine blood count, liver function, coagulation function and other relevant tests, and actively prepare for surgery. If the gallbladder stone is embedded in the neck, combined with biliary stasis and gallbladder enlargement, emergency laparoscopic cholecystectomy and anti-inflammatory treatment by intravenous infusion of anti-inflammatory drugs should be actively considered.