The kidneys are mainly excretory organs that excrete toxins from the body, including acidic metabolic wastes, and also excrete excess water. If patients have low glomerular filtration rate, they will have reduced excretion of metabolites, which can lead to symptoms caused by elevated blood creatinine and excessive toxins, such as nausea, vomiting, loss of appetite and itchy skin. In addition, patients can also experience accumulation of acidic metabolic wastes, leading to conditions such as metabolic acidosis and hyperkalemia. If water is not excreted effectively from the body, patients may develop water and sodium retention manifestations, such as hypertension or edema, and some patients may also develop cardiac insufficiency, heart failure, shortness of breath, and dyspnea. If patients have low glomerular filtration rate, nausea, vomiting, elevated creatinine, edema, hypertension and other symptoms, it is recommended to seek medical attention in time to clarify the cause of kidney disease and to provide effective treatment.