The first 1,000 days of life, from conception to 2 years of age, is an important theme that affects the future of humanity and is an important stage of early childhood development. For at-risk children, the period before 6 months is again the golden time of the 1000 days of life. During this period, a scientific and comprehensive intervention discourse is indispensable to promote the full development of the developmental potential of the at-risk child in terms of physical, psychological and social abilities. The important role of early childhood development in the developmental milestones of life has gradually been recognized. Every child should have the opportunity to realize his or her full potential and grow up to be a productive member of society. What is an at-risk child? At-risk infants are those who have risk factors for growth and development (especially brain development) during the fetal, delivery and neonatal periods. According to statistics, high-risk infants account for 10% to 20% of all newborns. High-risk infants are at potential risk of brain damage, which will lead to cerebral palsy, mental retardation, epilepsy and emotional and behavioral abnormalities, and are the main cause of disability in infancy and early childhood. Why should early comprehensive intervention be provided for high-risk infants? Scientific research proves that the younger the infant is, the more plastic the brain is and the better the ability to compensate for brain damage. Especially in the first year of life, especially the first few months, is a critical period for brain development, during this period, if you can receive systematic guidance from professional doctors to provide early comprehensive intervention, it is crucial for infants’ intellectual and motor development. Integrated intervention methods include audiovisual and tactile training, neurodevelopmental therapy, motor function training, physical therapy and parent-child activities. Early rehabilitation treatment is divided into early treatment (within 6 months after birth) and ultra-early treatment (within 3 months after birth) according to the time of treatment initiation.