Syphilis relapse after cure can be treated with long-acting penicillin and ceftriaxone sodium. If there is a recurrence of syphilis after cure, the first choice of drugs is usually penicillin, with long-acting penicillin as the main; penicillin-resistant people can choose ceftriaxone sodium. At the same time, you can also carry out the culture of syphilis or drug sensitivity test, and under the results of the drug sensitivity test to choose the appropriate antibiotics for treatment, and for the causes of syphilis recurrence such as incomplete treatment or drug resistance, targeted treatment. If syphilis recurs after cure, you should consult a doctor for timely examination and treatment for the cause, and the relevant drugs should be used under the guidance of a doctor.