Rheumatoid arthritis feel pain for the time being does not exist the most effective solution, can be under the guidance of the doctor, through the anti-rheumatic drugs such as methotrexate, glucocorticosteroids such as trimethoprim, non-steroidal anti-inflammatory drugs such as indomethacin and so on for treatment. 1. Anti-rheumatic drugs: Methotrexate alone can be recommended as the first choice under doctor’s supervision, as well as Leflunomide or Liuzasulfapyridine, Azathioprine, Cyclosporine, etc. alone. 2. Glucocorticosteroids: glucocorticosteroids are highly effective in anti-inflammatory and immunosuppressive effects, which can rapidly relieve the symptoms of arthritic swelling and pain and systemic inflammation, and can be used in the form of trimethoprim, betamethasone acetate and so on. 3. Non-steroidal anti-inflammatory drugs: the drug has analgesic and anti-inflammatory effects, commonly used drugs are indomethacin, ibuprofen, diclofenac, celecoxib, etc. for treatment. It is recommended that patients under the guidance of a doctor, strictly comply with the doctor’s instructions to use drugs, not blindly use drugs or unauthorized changes in drug dosage, so as not to cause adverse effects on the body, triggering the emergence of other diseases.