Babies with brain injury are at greater developmental risk, and it is even more important to do early intervention, which should start after hospital discharge, in order to prevent and mitigate the occurrence of disability. The earlier preterm babies are born, the more immature they develop and the more diseases occur in the neonatal period, the more severe the brain injury, most commonly respiratory distress syndrome, periventricular – intraventricular hemorrhage, asphyxia, infection,, hypoglycemia and nutritional deficiencies, etc., affecting the normal development of the brain. The typical manifestation of brain injury in preterm infants is paraventricular white matter softening, which can easily cause symmetrical spastic lower limb palsy and severe encephalopathy of prematurity, which can cause upper and lower limb cerebral palsy and mental retardation, as well as visual and hearing impairment and epilepsy. In contrast, preterm infants of older gestational age or babies with fewer diseases after birth will be at less risk of development if they do not have significant brain damage, and the vast majority can develop better if early intervention is performed.