Antidepressants taken for menopausal depression include, i. Selective 5-hydroxytryptamine reuptake inhibitors, such as paroxetine, fluoxetine, fluvoxamine, sertraline, citalopram, and so on. The largest number of antidepressants play an antidepressant role by selectively blocking the reuptake of 5-hydroxytryptamine. Second, selective norepinephrine inhibitors. Such as Maprotiline, Bupropion, Reboxetine, etc.. By selectively blocking the reuptake of norepinephrine, play the role of antidepressant. These drugs have poor selectivity and many adverse reactions, and their application is gradually decreasing. Third, 5-hydroxytryptamine and norepinephrine inhibitors. Such as venlafaxine, duloxetine, amitriptyline, clomipramine, doxepin and so on. At the same time block 5-hydroxytryptamine and norepinephrine reuptake, play the role of antidepressant. Fourth, monoamine receptor antagonists. Such as trazodone, mianserin, mirtazapine and so on. By inhibiting monoamine-related receptors, play an antidepressant role.