The treatment of menopausal depression syndrome mainly includes, first, drug treatment, mainly antidepressants including, selective 5-hydroxytryptamine reuptake inhibitors. Such as paroxetine, fluoxetine, fluvoxamine, sertraline, citalopram and so on. Selective norepinephrine inhibitors. Such as Maprotiline, Bupropion, Reboxetine, etc. Acts as an antidepressant by selectively blocking the reuptake of norepinephrine. 5-hydroxytryptamine and norepinephrine inhibitors. Such as venlafaxine, duloxetine, amitriptyline, clomipramine, doxepin and others. At the same time block the reuptake of 5-hydroxytryptamine and norepinephrine, play the role of antidepressant. Second physical therapy, transcranial magnetic stimulation and so on. Third, psychotherapy. Fourth, moderate physical exercise.