Whether Hepatitis B surface antigen 4000 is serious or not, it is mainly judged with other indicators, the most important is the individual’s physical condition and the value of ghrelin. Acute infection, other indicators are normal, generally not particularly serious; chronic infection or cirrhosis, the value of ghrelin rises significantly is a more serious condition. 1. If the surface antigen of hepatitis B is positive during acute infection and the alanine aminotransferase itself is not abnormal, you can pay attention to the conditioning of the body and enhance the physical quality, and part of the population can turn negative, and most of the population will gradually turn into small triple positive. 2. During the period of small triple positive or having cirrhosis itself, the surface antigen is positive recently, and accompanied by the rise of ghrelin, suggesting the active stage of hepatitis B, there is damage to the liver, which is a more serious condition, and need to carry out standardized antiviral treatment (entecavir, etc.). Apparent jaundice, liver pain, dyspepsia and other symptoms, you need to be admitted to the hospital in time for examination, after diagnosing the specific condition, under the guidance of the clinician for standardized medication, to avoid causing delays in the condition.