Right migraine and orbital pain may be a cluster headache, a primary neurovascular headache whose exact etiology is unclear. Patients generally present with stabbing, pins-and-needles pain, pulling, and tearing pain, and the headache is relatively severe and unbearable, which can affect the patient’s daily life and work, and can be accompanied by conjunctival congestion, nasal congestion, and lacrimation. Patients may have a certain regularity of headache, for example, the headache may come on 1-2 hours after sleep at night. The headache may also come on frequently during a certain season of the year, or it may come on during a certain period of time during a certain season. The main focus is on symptomatic treatment, usually with the application of trimipramine, commonly used as zolmitriptan and sumatriptan.